42例急性有机磷中毒合并中间综合征的临床分析

Clinical analysis of 42 cases of intermediate syndrome after acute organophosphorous pesticides poisoning

目的研究有机磷中毒合并中间综合征(IMS)患者预后的影响因素。方法回顾性分析42例有机磷中毒合并IMS患者的病例资料,包括一般情况、洗胃时间、气管切开与气管插管、血液灌流、机械通气时间,发生IMS的时间、心率、白细胞计数、胆碱酯酶活性等。根据生存情况分为生存组24例,死亡组18例。结果两组的心率、白细胞计数、胆碱酯酶、发生IMS的时间比较差异均无统计学意义(P<0.05)。生存组洗胃时间、气管切开、机械通气时间、血液灌流与死亡组比较差异均有统计学意义。结论洗胃时间、气管切开、机械通气时间、血液灌流是提高IMS患者抢救成功率的主要因素。

Objective To analyze the risk factors in the patients with intermediate syndrome（IMS） after acute organophosphorous pesticides poisoning（AOPP）.Methods The general condition,time of gastric lavage,tracheotomy or tracheal cannula,hemoperfusion,time of mechanical ventilation,in ICU or not,time of IMS accident happened,heart rates,acetylcholinesterase（AchE）,WBC count were collected in 42 patients with IMS after AOPP.The patients were divided into two groups：death group（18 cases） and survival group（24cases）.Results There were no statistical differences in heart rates,AchE,WBC count,in ICU or not,time of IMS incident happened between two groups.Time of gastric lavage,tracheotomy,hemoperfusion and time of mechanical ventilation were different between two groups（P0.05）.Conclusion Time of gastric lavage,tracheotomy,hemoperfusion,time of mechanical ventilation are the key factors to improve the survival rate of the patients with IMS.