5′位氨基修饰的核苷化合物的合成

Synthesis of 5′-amino Modified Nucleosides

以5-甲基尿苷为原料通过四步反应合成了5′位氨基修饰的核苷化合物,首先2′-OH和3′-OH进行保护得到2,′3′-位异丙叉基保护中间体,对5′位羟基进行Ts化后引入叠氮基,加入三苯基膦通过Staud inger反应形成氮磷双键后加水还原得到5′位氨基修饰的核苷化合物。

5′amino modified nucleoside compounds were synthesized through four steps.Firstly,2′,3′-isopropylidene intermediate was obtained through protecting of 2′,3′-hydroxyls by acetone,then introduction of azide after tosylation of 5′-hydroxy,5′position amino-modified nucleoside compound was got by the Staudinger reduction.