摘要
大鼠和仓鼠作为常用的降胆固醇研究模型而广泛应用。通过喂饲大鼠和仓鼠不同含量膳食胆固醇(0～0.9%),对大鼠和仓鼠高胆固醇模型进行比较。结果显示,仓鼠血清总胆固醇(TC)水平比同样膳食胆固醇含量组大鼠高73%～81%。与大鼠高密度脂蛋白胆固醇(HDL-C)含量只占血清总胆固醇很少比例不同,仓鼠的血脂组成与人类更为相近。并且,仓鼠小肠酰基CoA:胆固醇酰基转移酶(ACAT)活性将近是大鼠的20倍。
Rat and hamster are commonly used rodents to test the efficacy of cholesterol-lowering functional foods.The present study was carried out to compare hamsters with rats as a hypercholesterolemia model.Golden Syrian hamsters and Sprague Dawley rats were randomly divided into four groups and fed one of the four diets containing 0-0.9%cholesterol.Results demonstrated that serum total cholestero（lTC）in hamsters was raised 73 %-81 % higher than that in rats fed the same cholesterol diets.Unlike rats in which HDL-C accounted very little for serum TC,the lipoprotein profile in hamsters was closer to than in humans.And results also showed intestinal acyl coenzyme A： cholesterol acyltransferase（ACAT）activity in hamsters was almost twenty folds of that in rats.
出处
《食品研究与开发》
CAS
北大核心
2010年第5期10-14,共5页
Food Research and Development
基金
国家自然科学基金(No30671766)
