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聚甲基丙烯酸N,N-二甲氨基乙酯及其衍生物作为非病毒基因载体的研究进展

Research Progress of Poly(N,N-Dimethylamino Ethyl Methacrylate) and Its Derivatives Used as Non-viral Gene Vectors
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摘要 综述了聚甲基丙烯酸N,N-二甲氨基乙酯(PDMAEMA)及其衍生物作为非病毒基因载体的研究进展,包括PDMAEMA及其衍生物相对分子质量及结构与转染效率之间的关系、亲水性聚合物修饰的PDMAEMA和低相对分子质量的PDMAEMA接枝共聚物,并展望了PDMAEMA及其衍生物作为非病毒基因载体的发展方向。 The research progresses of poly（N,N-dimethylamino ethyl methacrylate）（PDMAEMA） and its derivatives used as non-viral gene vectors including the relationship of relative molecular mass and structures of PDMAEMA and its derivatives with their transfection efficiency,hydrophilic polymer modified PDMAEMA as well as low relative molecular mass PDMAEMA graft copolymers are reviewed.The development directions of PDMAEMA and its derivatives used as non-viral gene vectors are prospected.
作者 邢金峰 张玉清 邓联东 董岸杰
机构地区 天津大学化工学院 河南科技大学化工与制药学院
出处 《化学推进剂与高分子材料》 CAS 2010年第3期19-22,共4页 Chemical Propellants & Polymeric Materials
基金 教育部新教师基金(20090032120013) 天津市自然科学基金(No09JCYBJC13800)
关键词 聚甲基丙烯酸N N-二甲氨基乙酯 非病毒基因载体 转染效率 亲水性聚合物 poly（N N-dimethylamino ethyl methacrylate） non-viral gene vector transfection efficiency hydrophilic polymer
分类号 R450 [医药卫生—治疗学]
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参考文献20

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化学推进剂与高分子材料
2010年 第3期

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