粉尘螨滴剂治疗变应性鼻炎的临床疗效及安全性观察

Efficacy and safety of sublingual immunotherapy with dermatophagoides farianae drops in patients with allergic rhinitis

目的观察舌下含服粉尘螨滴剂治疗变应性鼻炎的临床疗效和安全性。方法对62例4～60岁粉尘螨皮肤点刺试验阳性的变应性鼻炎患者,采用"粉尘螨滴剂"舌下含服特异性免疫治疗,疗程满25周以上,根据变应性鼻炎疗效评定标准,进行临床疗效分析。结果 62例患者中显效13例,有效37例,无效12例。总有效率为80.65%,且70%的患者在一个月内起效。出现3例轻微不良反应,无严重不良反应病例。结论舌下含服"粉尘螨滴剂"能够安全有效的治疗变应性鼻炎,并且有很好的临床应用价值。

Aim To evaluate the efficacy and safety of sublingual immunotherapy with dermatophagoides farianae drops in patients with allergic rhinitis.Methods Sixty-two patients with allergic rhinitis due to dust mites received sublingual immunotherapy with dermatophagoides farinae drops for about 25 weeks,conjunct with standard drug therapy in the beginning phase to relieve the symptoms.Scores of rhinitis symptoms and the medication use were assessed before and after the treatment.Adverse events were observed throughout the trial.Results Thirteen patients（21.0%）showed excellent efficacy,thirty-seven patients（59.7%）moderate efficacy,and twelve patients（19.4%）no significant efficacy.Side effect occured in 3 cases.No serious adverse events were reported.70% of allergic subjects were effectively improved in the first month.Conclusion Dermatophagoides farinae drops is safe and effective in treating allergic rhinitis,and has favourable clinical values.