天然型复合网孔状羟基磷灰石在牙周骨缺损的应用研究

A clinical research of natural composite net space-like hydroryapatite in periodontal osseous defects

目的:研究新型牙周骨再生材料的临床应用价值。方法:实验1:用家兔10只,在家兔两侧背肌的肌囊内分别植入天然型网孔状羟基磷灰石(IHA)及天然型复合网孔状羟基磷灰石(IHA/BNP)。实验2:用家兔10只,条件同实验一。在两侧胫骨内分别植入IHA及羟基磷灰石(HA)。实验3:用家兔24只,在其31、32、33,41、42、43牙唇侧附着处做弧形切口,制备长为两切牙间距离的两壁骨缺损。将IHA/BMP或IHA植入已制备的骨缺损区内并压紧,严格缝合切口。临床应用:选用符合标准的52例牙周病患者的60颗患牙,随机分为IHA/BMP、IHA、HA(对照组)三组。结果:与骨形态形成蛋白质(BMP)复合,组成IHA/BMP,经动物实验证实该材料生物相容性良好,具有传导及诱导成骨功能,新生骨出现早、生长快,成骨量多。结论:天然复合网孔状羟基磷灰石(IHA/BMP)具有类似人骨的网状交联空隙,有利于传导成骨,牙根面也有少量新骨沉积。是当前修复牙周骨缺损较理想的人工替代材料。

Objective： To study a new type ideal periodontal regeneration materials. Methods： Experiment 1 ： with ten rabbits, IHA and HA were implanted into the muscular sac of the dorsal muscles respectively. Experiment 2： with ten rabbits, IHA end HA were implanted into the shinbone respectively. Experiment 3： with 24 rabbits,arc incision was made in the gingival attachment of 31,32,33,41,42,43, making the bone defects of two incisor teeth width, IHA/BMP or IHA were implanted into the bone defects and incisions were sutured tightly. Clinical application：selecting 60 teeth of 52 cases periodontal disease,divided into 3 groups randomly： HA/BMP.IHA.HA（being as control group）. Results： IHA/BMP combination were testified satisfactory biocompatibility, can transmit and induction bone formation, newly formed bone have the merit：bone formation earlier, growth quicker, more output.Conclusion： IHA/BMP combination have the cross- link cellule similar to human bone, can transmit and induction bone formation, small amounts new bone were deposited in the rhizoplane. IHA/BMP combination were relatively ideal periodontal regeneration materials currently.