新型抗精神病药对老年精神分裂症患者血清催乳素的影响

A investigation of effect of non-typical antipsychotics on serum prolactin level in senile patient with schizophrenia

目的:探讨几种新型抗精神病药对老年精神分裂症患者血清催乳素(PRL)的影响。方法:选取新型抗精神病药治疗老年精神分裂症120例,分别在治疗前后测定血清PRL水平。结果:经利培酮、喹硫平、齐拉西酮、阿立哌唑治疗后患者血清PRL明显升高,各药物之间以及治疗前后比较差异均有显著性(F=15.95,P<0.01)。PRL水平的升高与药物剂量呈正相关。阿立哌唑对PRL水平影响不明显。结论:几种非典型抗精神病药对老年精神分裂症患者PRL水平的影响同样明显,强弱的顺序依次是利培酮、喹硫平、齐拉西酮、阿立哌唑。

Objective： To investigation the effect of a few non - typical antipsychotics on serum prolactin（PRL） level in senile patient with schizophrenia.Methods： 120 senile patients with schizophrenia treated by non - typical antipsychotics, before treatment and after treatment respectively examining level of PRL.Results： The level of PRL increased highly after fisperidone, quetiapine, ziprasidone and aripiprazole treatment. Between four kinds medicament, between before and after treatment, there was a significant difference（ F = 15.95, P 〈 0.01 ）. The level of PRL was significantly correlated with dosage. However,less influence on level of PRL by aripiprasole. Conclusion： Non- typical antipsychoties as influence as typical antipsychoties on level of PRL in the treatment with senile schizophrenia. The intensity was risperidone, quetiapine, ziprasidone and aripiprasole in turn.