摘要
目的研究甘草酸的差向异构体在大鼠体内的药物动力学特征。方法大鼠按25mg.kg-1的剂量分别灌胃给予甘草酸2种差向异构体,使用HPLC测定血药浓度,以DAS2.0软件拟合药动学参数,并用SPSS统计软件对α-甘草酸组和β-甘草酸组的药动学参数进行比较。结果甘草酸的差向异构体在体内转化为甘草次酸后主要药动学参数分别为:α-甘草酸组AUC0-36为(57.04±14.64)μg.mL-1.h,Cmax为(4.68±2.56)μg.mL-1t1/2为(5.56±1.65)h,tmax为(10.0±4.0)h;β-甘草酸组AUC0-36为(36.55±13.18)μg.mL-1.h,Cmax为(4.24±1.69)μg.mL-1,t1/2为(7.88±2.40)h,tmax为(9.0±1.1)h。结论甘草酸的差向异构体在体内转化为甘草次酸后的主要药动学参数存在显著性差异。
Objective To determine the pharmacokinetic parameters of 2 epimers of glycyrrhizic acid （GL） after oral administration of α-GL and β-GL in rats.Methods α-GL and β-GL solvent were administered orally at a dose of 25 mg·kg-1.The concentration in the plasma was measured by HPLC method.Experimental data and the pharmacokinetic parameters were processed with the computer program DAS 2.0 and SPSS.Results The main pharmacokinetic parameters were：AUC0-36=（57.04±14.64）μg·mL-1·h;Cmax= （4.68±2.56）μg·mL-1 t1/2=（5.56±1.65）h,tmax=（10.0±4.0）h after oral administration of α-GL;AUC0-36=（36.55±13.18）μg·mL-1·h;Cmax=（4.24±1.69）μg·mL-1,t1/2=（7.88±2.40）h,tmax=（9.0±1.1）h respectively after oral administration of β-GL.Conclusion The main pharmacokinetic parameters of GA after the oral administration of α-GL and β-GL are different.
出处
《中南药学》
CAS
2010年第5期350-353,共4页
Central South Pharmacy
