血清超敏CRP、cTnI与HIE病情严重程度的相关性研究

Relevance of Serum High-Sensitivity C-Reactive Protein(Hs-CRP) and Troponin-I(cTnI) with Neonatal Hypoxic-Ischemic Encephalopathy(HIE) Severity

目的探讨血清超敏C反应蛋白(hs-CRP)、肌钙蛋白-I(cTnI)与新生儿缺氧缺血性脑病(HIE)病情严重程度的相关性。方法以60例HIE患儿作为病例组,30例无感染的黄疸患儿作为对照组,分别检测两组患儿血清中的hs-CRP、肌钙蛋白-I水平。结果 HIE患儿与对照组;重度组与中度组;重度组与轻度组;中度组与轻度组比较hs-CRP和cTnI均明显增高(P<0.05)。结论 HIE患儿hs-CRP和cTnI升高且与HIE的严重程度呈正相关,能较敏感的反映HIE患儿病情程度,可以作为HIE严重程度的临床监测指标之一。

Objective To investigate the relevance of serum high-sensitivity C-reactive protein（hs-CRP） and troponin-I（cTnI） with neonatal hypoxic-ischemicencephalopathy （HIE） severity. Methods ＇ Sixty infants with HIE were selected as study cases and thirty patients without infection in children with jaundice as control group. The serum troponin-I and hs-CRP levels in the two groups were measured, Results The hs-CRP and cTnI levels were significantly higher（ P 〈 0.05 ） as compared newborns with HIE to control group, severe group to moderate group, severe group to mild group, moderate group to mild group. Conclusion The variation of hs-CRP and cTnI levels in newborns with HIE is paralleled to the severity of the disease, which can sensitively reflect the severity of HIE. Therefore hs-CRP and eTnI levels may be used as the vital indexes for the evaluation of the severity of HIE.