埃索美拉唑根除HP感染消化性溃疡疗效观察

Therapeutic Effects of Esomeprazole on Peptic Ulcer Caused by Helicobacter Pylori Infection

目的观察埃索美拉唑三联疗法根除幽门螺旋杆菌(Helieobacter pylori,HP)感染消化性溃疡(Peptic Ulcer,PU)的临床疗效。方法将100例HP感染消化性溃疡按随机数字表法分为治疗组(埃索美拉唑+克拉霉素+阿莫西林)50例和对照组(奥美拉唑+克拉霉素+阿莫西林)50例,治疗1个疗程后,观察患者溃疡愈合和HP根除情况。结果与对照组比较,治疗组愈合率、总有效率明显高于对照组(P<0.05);治疗组HP根除率差异无统计学意义(P>0.05),但治疗组HP根除率高于对照组。结论以埃索美拉唑+克拉霉素+阿莫西林三联疗法在治疗消化性溃疡的愈合率、有效率方面明显优于奥美拉唑+克拉霉素+阿莫西林三联疗法,HP根除率高于奥美拉唑三联疗法,值得临床推广。

Objective To investigate the clinical effects of esomeprazole combined therapy in radical treatment of peptic ulcer （PU） caused by Helicobacter pylori （HP）. Methods 100 eases of peptic ulcer patients with HP infection were randomly divided into treatment groups（50 cases, treated by esomeprazole ＋ clarithromycin ＋ amoxicillin） and control group （50 cases, treated by omeprazole ＋ clarithromycin ＋ amoxicillin）. After a course of treatment ,The healing of ulcer and eradication rate of Hp were ob- served. Results The healing rate and total effective rate of the treatment group was significantly higher than that of the control group （ P 〈 0. 05 ）. There was no statistical difference in the rate of HP eradication between both groups （ P 〉 0. 05 ）. Conclusion The healing rate and total effective rate of the combined therapy with esomeprazole plus clarithromycin and amoxi- cillin are much better than that of the method with omeprazole plus clarithromycin and amoxicillin triple therapy with a relatively lower HP eradication rate.