摘要
目的改进扎托布洛芬的合成工艺。方法以邻氯苯乙酮和苯硫酚为原料,经Ullmann缩合、Willgerodt重排、闭环、Friedel-Crafts反应和1,2-芳香基重排等8步反应制得扎托布洛芬。结果总收率9.9%。结论本工艺操作简便,成本较低,适于工业化生产。
Objective To optimize the synthesis technology of zaltoprofen. Methods Starting from 2＇- Chloroacetophenone and phenylmercaptan, zaltoprofen was obtained via 8 chain steps including Ullmann condensation, Willgerodt rearrangement, cyclization, Friedel-Crafts reaction and 1,2-aryl shift, etc. Results The total yield of zaltoprofen was 9.9 %. Conclusion The synthesis technology of zaltoprofen is simple, easily controlled and cost-saving for the industrial production.
出处
《食品与药品》
CAS
2010年第5期171-173,共3页
Food and Drug
关键词
扎托布洛芬
合成
非甾体消炎药
zaltoprofen
synthesis
non-steroid antiphlogistic drug
