脐血脂联素、瘦素水平与胎儿发育的相关性

The relationship of cord blood leptin and adiponectin with fetus growth and development

目的探讨脐血脂联素、瘦素水平与胎儿生长发育的关系。方法选择2006年10月至2007年10月在我院产科出生的新生儿86例，根据不同出生体质量分为小于胎龄儿（SGA）组16例，适于胎龄儿（AGA）组41例，大于胎龄儿（LGA）组29例。胎儿娩出后立即断脐留脐血20IId，采用放射免疫分析法测定血清脂联素、瘦素水平，同时检测其血脂水平，测量新生儿生长参数，计算体质量指数（BMI）。结果（1）3组脐血瘦素和脂联素水平差异有统计学意义（P〈0．1301），LGA组明显高于AGA及SAG组（P〈0．01）；（2）脐血瘦素水平与体质量、胎龄、头围、身长、足长及胎盘重量呈正相关（P〈0．01），脐血脂联素水平与出生体质量、头围、足长、B／VU水平呈正相关（P〈0．05）。（3）脐血瘦素与脂联素水平呈显著正相关（P〈0．01）。（4）3组血脂水平比较差异无统计学意义；脐血脂联素、瘦素水平与血脂各指标间无明显相关性（P〉0．05）。结论瘦素与脂联素在胎儿宫内生长和发育过程中起重要的调节作用。

Objective To investigate the relationship between the levels of adiponectin and leptin in umbilical bloods and fetal＇ s growth and development. Methods Eighty-six neonates born in our obstetrics department from October 2006 to October 2007 were enrolled the study. According to different birth weight they were divided into small for gestational age infants （SGA） group（ n = 16）, appropriate for gestational age （AGA） group（ n = 41） and large for gestational age （LGA） group （n = 29 ）. After the baby was delivered, 20ml umbilical cord blood was collected immediately.Serura adiponectin and leptin levels of umbilical blood were measured using the radio immunoassay, while blood lipid levels were examined and neonatal growth parameters were measured. Results （1）There were significant difference of umbilical blood leptin and adiponectin levels among three groups（ P 〈 0.001）, which were higher in LGA group than those in AGA and SAG group（ P 〈 0.01）. （2）There were positive correlations between the serum leptin levels and body weight, gestational age, head circumference, body length, foot length and placental weight（ P 〈 0.01 ）. There were positive correlations between the umbilical blood levels of adiponeetin and birth weight, head circumference, foot length and BMI （ P 〈 0.05）. （3） Umbilical blood leptin levels were significantly positively correlated with adiponectin （ P 〈0.01）. （4） Blood lipid levels were not found significant difference among three groups, there were no significant correlation between umbilical blood adiponectin and leptin levels and blood lipids （ P 〉 0.05）. Conclusion Umbilical blood lepfin and adiponectin play an important role in fetal growth and developmental processes.