摘要
CD28-B7家族成员属于免疫球蛋白超家族，它们之间相互作用向T细胞传递共刺激信号，在T细胞的活化、增殖、抗凋亡及促进多种细胞因子的分泌中起重要作用。近几年的研究发现CD28-B7家族与肿瘤、自身免疫性疾病等发生有重要关系。
The CD28-B7 are members of immunoglobulin superfamily.When B7 is engated by the CD28 ligand, a costimulatory signal occurs and transfers to T cell and it is important in the activation, proliferation, anti-apoptosis and promoting cytokine secretion of T cell. The CIY28-B7 family is associated with tumor and autoimmune disease.
出处
《国际儿科学杂志》
2010年第3期254-257,共4页
International Journal of Pediatrics
