Toll样受体在哮喘中的研究进展

Progress of Toll-like receptors in asthma

支气管哮喘是一种多基因与环境共同参与的复杂疾病，其发病机制和治疗策略的研究越来越受到人们的关注。Toll样受体（TLR）及其信号传导途径可调节哮喘相关的免疫细胞，并诱导或抑制哮喘的发生发展。它是一种模式识别受体，能依赖基因编码的保守序列识别病原微生物，同时激活固有免疫，调节获得性免疫和诱导免疫耐受。

Asthma is heterogeneous disorder which caused by a complicated interaction between multiple genes and environmental factors. A increasing number of attention has paid in the researches about its pathogenic mechanism and therapeutic strategies. Not only can Tol-like receptors and signal transduction pathways mediate relevant immunocyte of asthma, but also induce or restrain development of asthma. TLRs is a kind of pattern recognition receptor（PRRs）, which can rely on the conserved sequence of gene encoding to identify pathogenic microorganism, meanwhile activate innate immunity, adjust acquired immunity and induce immune tolerance.