经皮冠状动脉介入术后患者血小板抑制率的血栓弹力图测定

Platelet Inhibition Ratio by Thromboelastography in Patients Undergoing Percutaneous Coronary Intervention

目的探讨经皮冠状动脉介入治疗(PCI)的患者中,使用血栓弹力图(TEG)所测定的血小板抑制率的变化及临床意义。方法根据6个月内有无再发缺血事件,将入选的118例PCI患者分为缺血事件组22例与非缺血事件组96例,计算两组患者经TEG测定的血小板抑制率。结果缺血事件组与非缺血事件组患者相比较,二磷酸腺苷诱导的血小板抑制率明显降低(P<0.01),而花生四烯酸诱导的血小板抑制率无显著性差异(P>0.05)。结论冠心病患者PCI术后缺血事件的发生,可能与对氯吡格雷的抵抗有关。

Objective To investigate the platelet inhibition ratio by thromboelastography （TEG） and its clinical impact in patients undergoing percutaneous coronary intervention （PCI）.Methods 118 PCI patients were divided into ischemic events group （22 cases） and nonischemic events group （96 cases） according to their clinical follow-up of 6 months.Platelet inhibition ratio was measured by TEG.Results ADP-induced platelet inhibition ratio of ischemic events group decreased significantly compared with nonischemic events group （P0.01）.And there were no significant differences in AA-induced platelet inhibition ratio between two groups （P0.05）.Conclusion There may be some relationship between the ischemic events of PCI patients and their drug resistance to clopidogrel.