中医虚证与食管癌生物学行为关系的研究

Study on Relationship between Deficiency Syndrome of TCM and the Biological Behavior in Patients of Esophageal Carcinoma

目的：研究中医虚证与食管癌淋巴结转移、浸润深度和ＴＮＭ分期等生物学行为的关系及在食管癌诊断和预后评价中的意义。方法：根据中医辨证标准，在手术前将１０１例患者分为食管癌伴有虚证和不伴有虚证两组。收集记录患者的辅助检查、术中所见、术后病理检查结果等。结果：１０１例患者中有３８例（３７６％）患者有不同程度的中医虚证表现，其中气虚１４例，阴虚１０例，气阴两虚１０例，气血两虚２例，阳虚１例，阴阳两虚１例。两组食管癌患者的浸润深度、淋巴结转移和ＴＮＭ分期等的构成比不同：食管癌伴有虚证组患者比不伴有虚证组患者的癌细胞浸润深度深，淋巴结转移重，ＴＮＭ分期晚，差异具有统计学意义（Ｐ＜００５）。结论：中医虚证与食管癌的生物学行为有较密切的关系，食管癌确诊后伴有虚证患者的预后比不伴有虚证患者差。

Objective: To investigate the relation between Deficiency Syndrome (DS) of TCM and the invading depth, lymphnode metastasis, TNM stage and prognosis prediction of esophageal carcinoma. Methods: According to Syndrome Differentiation of TCM, 101 patients of esophageal carcinoma were evaluated before operation and divided into two groups, the DS group and the non DS group. Results: Thirty eight cases in the 101 patients were DS, among them, 14 were Qi Deficiency, 10 Yin Deficiency, 10 Qi Yin Deficiency, 2 Qi and blood Deficiency, 1 Yang Deficiency and 1 Yin Yang Deficiency. There were significant differences between the DS group and non DS group in the invading depth (deeper in DS), metastasis of lymphnode (severer in DS) and TNM stage (later in DS) of esphageal carcinoma, (P<0 05). Conclusion: There is a significant relation between DS and the biological behavior of esophageal carcinoma. The prognosis of DS patients is poorer than that of the non DS patients.