480例肾组织活检病理资料回顾性分析

A summary on the pathological data from 480 cases of renal biopsy

目的了解医院驻地肾脏病病理类型。方法参照WHO1982年及改良的1995年肾小球疾病组织学分型方案,对2005-01～2009-07的480例肾脏活检患者临床资料、实验室检查结果和光镜、免疫病理、电镜的改变特点,结合临床确定诊断,回顾性总结480例肾组织活检的病理结果。结果患者年龄3~78岁,平均（34.1±15.2）岁,男女之比1.16：1。原发性肾小球疾病占首位为72.5%,继发性肾小球疾病为16.67%。原发性肾小球疾病的病理类型中最多见者为IgA肾病37.36%,其次为系膜增生性肾小球肾炎34.20%。继发性肾小球疾病中狼疮性肾炎占首位28.75%,其次为紫癜性肾炎21.25%。结论 150医院所驻地区肾脏疾病多见于青中年,以原发性肾脏疾病最常见,其中IgA肾病是最常见的病理类型,其次为系膜增生性肾小球肾炎。继发性肾小球疾病以狼疮性肾炎和紫癜性肾炎多见。

Objective To retrospectively summarize the pathological data from 480 cases of renal biopsy so as to understand the pathologic patterns of renal diseases develaped in the region of the located hospital.Method The 480 cases of renal biopsy were done by kidney department of the 150th central hospital of PLA between January 2005 and July 2009.Pathological classifications were made according to the WHO criteria（1982） for renal pathology or the modified WHO criteria（1995） by a panel of pathologists and nephrologists in routine clinicopathological rounds.Result The mean age of patients at renal biopsy was 34.1±15.2（3-78） years,the male/female ratio was 1.16：1.Primary glomerular diseases（PGD） accounted for 72.5% of the total renal patients biopsies;secondary glomerularnephritis（SGN）,16.67 %.IgA nephropathy（IgAN） was the most frequent patholigic type（37.36%） of PGD,followed by mesangial proliferative lesion（MsPL）（34.20%）.The most frequent type of SGN was lupus nephritis（LN）（28.75%）,followed by Henoch-Schonlein purpura glomerulonephritis（HSPN）（21.25%）.Conclusion In the region where No.150 hospital located in renal diseases often happen in young people.Primary glomerulonephritis is the most common renal glomerular disease with IgAN occupying the largest part,followed by MsPL.Secondary glomerularnephritis is mainly LN,followed by HSPN.