大剂量盐酸氨溴索注射液治疗COPD急性发作临床观察

Effects of high dose mucosolvin on acute exacerbation chronic obstructive pulmonary disease

目的:探讨大剂量盐酸氨溴索注射液在治疗慢性阻塞性肺疾病(COPD)急性发作中的临床疗效。方法:将80例COPD急性发作的入选患者随机分为大剂量组和常规剂量组,分别给予盐酸氨溴索注射液270、30mg/d静脉滴注,共7d。观察并比较两组间治疗前后的临床症状、疗效及平均住院天数。结果:两组均有效,有效率差异无统计学意义(P>0.05),大剂量组显效率明显高于常规剂量组(P<0.05),平均住院天数明显低于常规剂量组(P<0.05)。结论:盐酸氨溴索注射液治疗COPD急性发作是安全有效的,大剂量疗效更佳。

Objective：To investigate the clinical value of high dose mucosolvin on acute exacerbation chronic obstructive pulmonary disease（AECOPD）.Methods：80 patients of AECOPD were divided into 2 groups randomly, high dose group was treated with a high dose of mucosolvin（270 mg/day）, normal dose group were treated with normal dose of mucosolvin（30 mg/day）.Measured and compared clinical symptoms,curative effect and the average hospital day between two groups before and after the treatment.Results：There was no significant difference of effective rate between two groups（P0.05）.In the high dose group,excellence rate was higher than that of the normal dose group（P0.05）, the average hospital day was shorter than that of the normal dose group（P0.05）.Conclusion：The treatment of mucosolvin on AECOPD is safety and effective.High dose is more effective.