嗜吞噬细胞无形体致病机理的研究进展

Advance in Pathogenesis of Anaplasma phagocytophilum

嗜吞噬细胞无形体是一种侵染中性粒细胞专性细胞内寄生的革兰阴性菌,其所致疾病为人粒细胞无形体病(HGA),是一种经蜱传播的人兽共患病。它感染中性粒细胞后可诱发机体产生炎症免疫反应,最终导致免疫抑制及潜在疾病引起的各种继发感染和器官衰竭,甚至危及生命。近年来该病原体日益受到人们的关注和重视。就嗜吞噬细胞无形体致病机理研究的进展进行了综述。

Anaplasma phagocytophilum（Ap）,an obligate parasitic gram-negative bacterium that infected neutrophilic granulocyte,and the cause human granulocytic anaplasmosis（HGA）,is a tick-borne zoonosis.It could infect neutrophils and stimulate the body to produce inflammation immune response that ultimately lead to various secondary infections and organ failure caused by immunosuppression and potential diseases,even life-threatening.This pathogen has attracted more and more attention.The pathogenesis of the Ap is reviewed in this article.