小剂量红霉素治疗早产儿喂养不耐受疗效观察

Observation on therapeutic effect of erythromycin in small dose on premature babies with feeding intolerance

目的:观察小剂量红霉素治疗早产儿喂养不耐受的疗效及安全性。方法:将208例喂养不耐受的早产儿随机分为观察组106例和对照组102例,两组早产儿均给予保暖、口胃管饲、静脉营养等综合治疗,观察组在综合治疗基础上加用红霉素2～8mg.kg-1.d-1静脉滴注5～10d。结果:1观察组疗效(呕吐症状减少、食管钡餐造影返流次数减少、体重增加)明显优于对照组(P<0.001)。2观察组胃管留置时间、达胃肠道营养时间、增至出生体重时间、静脉营养时间、住院时间均比对照组明显缩短(P均<0.01)。结论:小剂量红霉素治疗早产儿喂养不耐受疗效显著、安全性好,具有广阔的应用前景。

Objective：To observe the therapeutic effect of erythromycin in small dose on premature babies with feeding intolerance.Methods：A total of 208 premature babies with feeding intolerance were randomly divided into observation group（106 cases） and control group（102 cases）.The comprehensive treatment such as keeping warm,mouth-stomach tube feeding,parenteral nutrition and so on were carried out in both groups.Intravenous drop infusion erythromycin 2～8m/kg perday was used on observation group for 5 to 10 days.Results：①The therapeutic effect of observation group were superior to the control group （P〈0.001）.②The time of retaining stomach tube,getting gastrointestinal tract nutrition,achieving birth weight,total parenteral nutrition and hospitalization in observation group were shorter than that of control group（P〈0.01）.Conclusion：The erythromycin in small dose can improve the feeding intolerance of premature babies.It is worthy of application.