99TcmO4-与99Tcm-HL91联合显像对甲状腺结节的诊断价值

Diagnosis of thyroid carcinoma using 99TcmO4-/99Tcm-HL91 imaging

目的用99Tcm-高锝酸钠（99TcmO4-）与99Tcm-4，9-二氮一3，3，10，10-四甲基十二烷-2，11-二酮（99Tcm-HL91）联合显像鉴别甲状腺结节的性质，评价其临床价值。方法对65例甲状腺结节患者行99TcmO4-动、静态双时相显像，48h后再对其进行99TcmO4-静态显像，显像结果示为冷结节的46例患者再行99Tcm-HL91乏氧显像，最后将两种显像结果与病理活检结果进行对比分析。结果99TcmO4-显像对甲状腺结节诊断的灵敏度、特异度和准确度分别为78．6％、71．9％、73．9％；99Tcm-HL91显像为88．7％、92．3％、91．4％，两者联合显像对甲状腺结节的诊断灵敏度为92．9％、特异度为93．8％、准确度为93．5％。结论99TcmO4-与99Tcm-HL91两种显像方法相结合有助于提高诊断符合率。

Objective To evaluate the clinical value of 99Tem-sodium perteehnetate （99TcmO4-） and 9OTcm-4, 9-diaza-3, 3, 10, 10-tetramethylododecan-2, 11-dione dioxime（99Tcm-HL91） imaging in differentiation of thyroid nodules. Methods 99TcmO4-dynamic and static imagings were performed to the 65 cases of patients with thyroid nodules. After 48 hours, the 46 cases of patients whose 99TcmO4- static imaging prompt cold nodules underwent 99Tcm-HL91 hypoxia imaging. And finally, compare the results of the two types imaging with biopsy results. Results The sensitivity, specificity and accuracy of 99TcmO4- imaging in the diagnosis of thyroid nodules were 78.6%, 71.9% and 73.9% respectively. The sensitivity, specificity and accuracy of 9STcm-HL91 imaging in the diagnosis of thyroid nodules were 88.7%, 92.3% and 91.4% respectively. And the sensitivity, specificity and accuracy of Combining 999TcmO4-/99Tcm-HL91 imaging were 92.9%, 93.8% and 93.5% respectively. Conclusion Combining 99TcmO4- and 99Tcm-HL91 imaging methods can improve the coincidence.