电离辐射诱导旁效应的研究现状

Bystander effect induced by ionizing radiation and its application

辐射旁效应是一种电离辐射引起的间接效应。国内外许多研究者应用先进的检测技术和方法证实了旁效应的存在，并对其机制有了更深入的了解，旁效应研究也逐渐从单细胞扩展到多细胞，从离体扩展到整体，从体外扩展到体内，为解释旁效应的发生及调控机制提供了有力的证据，尤其为以后的放射肿瘤临床应用提供科学的依据。

An indirect effect induced by ionizing radiation called bystander effect is being highly concentrated. Many domestic and foreign researchers have verified the existence of bystander effect and have got more understanding of the mechanism with advanced detection techniques and methods. So far, the research about it has expanded from a single cell to multiple cells, from the in vitro to the whole, and has extended to in vivo from in vitro, which provides powerful evidence to explain how bystander effects happen and the regulation mechanism and especially gives scientific evidence to clinical radiation oncology application in the future.