凯西莱预防抗肿瘤药物致肝损害的临床疗效

Clinical Effect of Tiopronin in Prevention of Hepatotoxicity Caused by Anti-tumor Agents

目的探讨凯西莱预防抗肿瘤药物致肝损害的临床疗效。方法将2004年3月-2008年8月入住我院的肿瘤病人116例随机分为凯西莱(硫普罗宁)治疗组65例,单纯化疗对照组51例。观察两组患者血清ALT、AST、TBIL情况及肝损害发生率。结果治疗组血清ALT、AST、TB较对照组明显降低,差异均有统计学意义(P<0.05);治疗组和对照组化疗后肝功能指标均明显低于化疗前,差异有统计学意义(P<0.05)。治疗组仅6例患者出现肝损害(9.23%),明显低于对照组肝损害发生率(16/51,31.4%)。结论在化疗期间使用抗肿瘤药物的同时加用凯西莱,能预防抗肿瘤药物致肝损害,值得临床进一步推广使用。

Objective To explore the clinical effect of tioprpnin in preventing hepatotoxicity induced by anti-tumor agents.Methods Totally 116 inpatients with cancer in Tumor Hospital of Harbin Medical University from March,2004 to August,2008 were randomly divided into tioprpnin group （n=65） and simple chemotherapy group （n=51）.The serum levels of alaninc aminotransferase （ALT）,aspartate aminotransferase （AST）,and total bilirubin （TBIL）,and the incidence rate of hepatotoxicity were compared between the two groups.Results The serum levels of ALT,AST,TBIL of tioprpnin group were significantly decreased than those of simple chemotherapy group,and the difference was statistically significant （P〈0.05）.After the treatment,the indexes of liver function of the two groups were both significantly lower than those of the two groups before the treatment,and the difference was statistically significant （P〈0.05）.There were 6 patients appeared liver injury （9.23%） in tioprpnin group,which was significantly less than that of simple chemotherapy group （16/51,31.4%）.Conclusions Combination use of anti-tumor drugs and tioprpnin during the chemotherapeutic period could effectively prevent hepatotoxicity induced by anti-tumor drugs.It is worthy of being popularized and applied in clinic.