慢性肾衰竭患者血清KYN和KYNA测定临床应用初探

Clinical Application of Determination of Serum Kynurenic Acid and Kynurenine in Patients with Chronic Renal Failure

目的探讨慢性肾功能衰竭(CRF)中血清犬尿氨酸(KYN)和犬尿喹啉酸(KYNA)含量以及KYNA/KYN比值的临床意义。方法测定慢性肾衰(CRF)患者(n=76例)血清KYN、KYNA含量,探讨慢性肾衰患者不同阶段血清KYN和KYNA含量变化及其在鉴别诊断、治疗监测、机制研究等方面的临床意义。结果与正常对照组相比,CRF组血清KYN和KYNA含量显著升高(P<0.01);CRF组患者各阶段血清KYN和KYNA含量随病情发展升高(P<0.01)。CRF组血清KYN和KYNA含量与肾功能状态有一定相关性。结论通过对CRF患者血清KYN和KYNA含量的测定,结果表明CRF患者血清KYN和KYNA含量随病情发展发生变化,并与血清BUN和CR等肾功能指标相关。

Objective To explore the clinical significance of determination of serum KYN and KYNA in patients with chronic renal failure （CRF）. Methods The concentrations of serum KYN and KYNA in CRF patients （n=76） were determined to explore the clinical significance of serum KYN and KYNA determined in different progresses of CRF. Results Compared with control group, the concentrations of serum KYN and KYNA in CRF group were significantly increased （P 〈 0.01）. The concentrations of serum KYN and KYNA in different stages of CRF patients were increased with the development of CRF （P〈0.01）. In CRF group, the concentrations of serum KYN and KYNA shewed positive correlation with renal function. Conclusions The results suggest that the concentrations of serum KYN and KYNA of CRF patients alter with the development of CRF, and are positively correlated with serum BUN and GR.