摘要
通过建立光动力治疗过程中激光、光敏剂、氧及其相互作用关系的数学模型,对组织中光动力剂量进行了模拟,研究了光动力剂量在组织内部分布变化的规律。模拟了激光剂量为50mW/cm2、100mW/cm2、150mW/cm2,光敏剂质量浓度为10mg/kg、20mg/kg、40mg/kg时光动力剂量变化。研究发现光动力剂量在组织内分布是非线性的,大小受激光强度、光敏剂剂量、氧浓度和组织光学参数等因素的影响,且光敏剂浓度的变化对光动力剂量变化的影响尤为明显。
Through establishing mathematical relation model of laser,photo-sensitizer and oxygen,photodynamic dose （PDD） in tissue was simulated and its distribution was studied. The change of PDD under the different laser doses of 50mW/cm^2,100mW/cm^2 and 150mW/cm^2 and the photo-sensitizer concentrations of 10mg/kg,20mg/kg and 40mg/kg were simulated. It is concluded that the PDD,an inhomogeneous value in the tissue,changes with many factors such as laser dose,photo-sensitizer and oxygen,and it is obviously effected by the variation of photo-sensitizer concentration.
出处
《应用光学》
CAS
CSCD
北大核心
2010年第3期512-516,共5页
Journal of Applied Optics
