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吡格列酮对胰岛素抵抗细胞糖代谢糖异生的影响

Effect of pioglitazone on glymetabolism and glyconeogenesis in insulin resistance cells
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摘要 目的:研究吡格列酮对胰岛素抵抗细胞糖代谢糖异生的影响。方法:采用地塞米松诱导3T3-L1脂肪细胞复制胰岛素抵抗模型,观察吡格列酮对胰岛素抵抗细胞葡萄糖消耗、糖异生的影响。结果:吡格列酮能显著增加胰岛素抵抗细胞的葡萄糖消耗,并且与胰岛素有协同抑制胰岛素抵抗3T3-L1脂肪细胞糖异生的作用。结论:吡格列酮可通过抑制糖异生途径改善胰岛素抵抗细胞的糖代谢。 Objective： To investigate the effect of Pioglitazone on glymetabolism and glyconeogenesis with insulin resistance ceils. Methods： To observe the impact of Pioglitazone on glymetabolism and glyeoneogenesis with insulin-resistant 3T3-L1 adipoeytes cell model. Results： Pioglitazone significantly increased the consumption of glucose in insulin resistance cells, and the repression of glyconeogenesis by Pioglitazone in 3T3-L1 adipoeytes cell can supported by the addition of insulin. Conclusion： Pioglitazone improve the glymetabolism through the glyconeogenesis pathway in insulin resistance cells .
作者 韩坤 李德恒 袁磊
机构地区 漯河医学高等专科学校生理教研室
出处 《四川生理科学杂志》 2010年第2期73-74,共2页 Sichuan Journal of Physiological Sciences
关键词 3T3-L1脂肪细胞 胰岛素抵抗 糖代谢 糖异生 3T3-L1 adipocytes Isulin resistant Glymetabolism Glyconeogenesis
分类号 R587.1 [医药卫生—内分泌]
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参考文献10

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四川生理科学杂志
2010年 第2期

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