复方三氮唑核苷注射液对大白鼠的亚慢性毒性试验

Subchronic Toxicity Test of Ribavirin Compound in Rat

将复方三氮唑核苷注射液按高、中、低剂量分别给大白鼠皮下注射，每天１次，连续注射３０ｄ，观察试验鼠的生理状态及活动情况，测定增重及血液生理生化指标，并进行病理解剖及病理组织学检查。结果表明，复方三氮唑核苷注射液对大白鼠的生理活动、血液生理生化指标均无不良影响；病理组织学检查，仅高剂量组有１０％大白鼠发生肾小管上皮细胞轻度颗粒变性，其它组各器官均未见异常。

rats randomly divided into 4 treatment groups. They were provided ribavirin compound 27.29 (LD 50 1/10), 13.64 (LD 50 1/20), 9.10 (LD 50 1/30)) and 0 mg/100g body weight by hypodermic injection one time a day, respectivily. The experimental period were 30 days . The research results showed that ribavirin compound has no poisonous effects in normal activities, physiological index and biochemical index in rats.