期刊文献+

妊娠期高血压疾病患者胎盘组织表皮生长因子受体表达 被引量:1

原文传递
导出
摘要 目的:观察妊娠期高血压疾病患者胎盘组织表皮生长因子受体(EGFR)蛋白质的表达和EGFRmR-NA的表达。方法:应用免疫组织化学的方法测定胎盘滋养层细胞表皮生长因子受体(EGFR)的表达,以及应用RT-PCR技术对EGFRmRNA进行定量分析。结果:妊娠期高血压疾病患者胎盘组织EGFR和EGFRmRNA的表达低于对照组,差异有统计学意义(P<0.01)。结论:妊娠期高血压疾病患者胎盘滋养层细胞EGFRmRNA转录减少,最终导致EGFR的蛋白质表达减少,影响其生物学作用。
作者 刘岚
出处 《中国误诊学杂志》 CAS 2010年第15期3568-3568,共1页 Chinese Journal of Misdiagnostics
  • 相关文献

参考文献3

  • 1Hsu SC, Hung MC. Characterization of a novel tripartite nuclear localization sequence in the EGFR family[J]. J Biol Chem,2007, 282(14) : 10432 -10440.
  • 2Milchev N,Batashki I, Staribratova D,et al. Trophoblast expression of EC-FR (epidermal growth factor receptor) in the preeclampsia placenta[J].Akush Ginekol (Sofiia), 2006,45 (2) : 21-24.
  • 3代先凤,邹翠兰.胎盘生长因子与妊娠期高血压疾病的关系[J].现代医药卫生,2006,22(3):360-362. 被引量:2

二级参考文献20

  • 1Polliotti BM,AG,Saller DN,et al.Second-trimester maternal serum placental growth factor and vascular endothelial growth factor for predicting severe,early-onset preeclampsia[J].Obstet Gynecol,2003101(6):1266.
  • 2Levine R.J,Thadhani R, Qian C,et al.Urinary placental growth factor and risk of preeclampsia[J].J AMA,2005,293(1):77.
  • 3Wen Yang, Henry Ahn,Monica Hinrichs,et al Evidence of a novel isoform of placenta growth factor (PLGF-4)expressed in human trophoblast and endothelial cells[J].Journal of Reproductive Immunology,2003,60(1):53.
  • 4Helske S,Vuorela P, Carpen O, et al.Expression of vascular endothelial growth factor receptors 1,2 and 3 in placentas from normal and complicated pregnancies[J].Molecular Human Rrproduction,2001,7(2):205.
  • 5Mamluk R,Gechtman Z,Kutcher ME,et al.Neuropilin-I binds vascular endothelial growth factor 165,placenta growth factor-2,and heparin via its b1b2 domain[J].Journal of Biological Chemistr,2002,277(27):24818.
  • 6Neufeld G, Kessler O,Herzog Y,et al The interaction of Neuropilin-1 and Neuropilin-2 with tyrosine-kinase receptors for VEGF.[Review] [34 refs]Advaces in Experimental Medicine & Biology[J].2002,515:81.
  • 7De Falco S.Gigante B.Persico MG,et al Structure and function of placental growth factor[J], [Reviewl [40 refs] Trends in Cardiovascular Medicine, 2002,12(6):241.
  • 8Lang I, Hoffman C, Olip H, et al. Differential mitogenic responses of human macrovascular and microvascular endothelial cells to cytokines underline their phenotypic heterogeneity[J].Cell Proliferation,2001,34(3):143.
  • 9Lash GE,Warren AY,Underwood S,et al.Vascular endothelial growth factor is a chemoattractant for trophoblast cells[J]. Placenta, 2003,24(5):549.
  • 10Crocker IP, Strachan BK,Lash GE,et al.Vascular endothelial growth factor but not placental growth factor promotes trophoblast syncytialization in vitro[J].Journal of the Society for Gynecologic Investigation,2001,8(6):341.

共引文献1

同被引文献17

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部