1Tulinsky A. Molecular interactions of thrombin. Semin Thromb Hemost, 1996, 22(2): 117-124.
2Camerer E, Huang W, Coughlin SR. Tissue factor-α and factor Xdependent activation of protease-activated receptor 2 by factor VIIa.Proc Natl Acad Sci USA, 2000, 97(10): 5255-5260.
3Kaufinann R, Patt S, Zieger M, et al. The two-receptor system PAR-1/PAR-4 mediates α-thrombin-induced [Ca(2 +) ] ; mobilization in human astrocytoma cells. J Cancer Res Clin Oncol, 2000, 126(2):91-94.
4Bartha K, Domotor E, Lanza F, et al. Identification of thrombin receptors in rat brain capillary endothelial cells. J Cereb Blood Flow Metab, 2000, 20(1 ): 175-182.
5Turgeon VL, Lloyd ED, Wang S, et al. Thrombin perturbs neurite outgrowth and induces apoptotic cell death in enriched chick spinal motoneuron cultures through caspase activation. J Neurosci, 1998,18(17): 6882-6291.
6Lee KR, Kawai N, Kim S, et al. Mechanisms of edema formation after intracercbral hemorrhage: effects of thrombin on cerebral blood flow, blood-brain barrier permeability, and cell survival in a rat model. J Neurosurg, 1997, 86(2): 272-278.
7Lee KR, Drury Ⅰ, Vitarbo E, et al. Seizures induced by intracerebral injection of thrombin: a model of intracerebral hemorrhage. J Neurosurg, 1997, 87(1): 73-78.
8Turgeon VL, Milligan CE, Houenou LJ. Activation of the proteaseactivated thrombin receptor (PAR)-I induces motoneuron degeneration in the developing avian embryo. J Neuropathol Exp Neurol,1999, 58(5): 499-504.
9Donovan FM, Pike CJ, Cotman CW, et al. Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities. J Neurosci, 1997, 17(14): 5316-5326.
10Striggow F, Riek M, Breder J, et al. The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations. Proc Natl Acad Sci USA, 2000, 97(5): 2264-2269.
