脓毒症微循环障碍的红细胞流变性改变

Alterations of Red Blood Cell Rheology in Microcirculation Dysfunction of Sepsis

脓毒症是一个复杂的病理生理过程,涉及微循环、血液主要成分的生理生化改变。红细胞流变性的恶化可损害微循环和组织氧供需平衡,进而导致多器官功能衰竭和死亡。红细胞的流变性受多因素影响,包括细胞内的Ca2+浓度、ATP、2,3-二磷酸甘油酸水平的改变、一氧化氮和温度的作用以及白细胞的相互影响等。现主要就脓毒症的红细胞流变性改变和可能的影响机制予以综述。

Sepsis is a complex pathophysiological process that involves both alterations in the microcirculation and changes in the biochemical and physiological characteristics of the blood constituents.Deterioration in erythrocyte rheology plays a crucial role in the impairment of microcirculation and tissue oxygenation that can lead to multiple organ failure and death.Erythrocyte rheology can be influenced by many factors,including alterations in intracellular Ca^2＋,ATP,and 2,3-diphosphoglycerate in addition to the effects of nitric oxide and temperature,and interactions with leucocyte This review focuses on the alterations in erythrocyte rheology and the possible underlying mechanisms of sepsis.