干扰素对MCF-7乳腺癌细胞的增殖抑制作用

DEPRESSANT EFFECTS OF INTERFERON ON PROLIFERATION OF MCF-7 BREAST CANCER CELLS

目的:研究干扰素对MCF-7乳腺癌细胞的增殖抑制作用。方法:MTT法检测干扰素-γ(IFN-γ)、干扰素-α2b(IFN-α2b)单独及联合应用,作用不同时间对MCF-7乳腺癌细胞的增殖抑制作用。结果:IFN-γ、IFN-α2b及二者联合应用均对MCF-7乳腺癌细胞的增殖具有抑制作用:单独用药时,作用48h的抑制作用较为明显(P<0.05);联合用药时,作用72h效果显著(P<0.05)。结论:IFN-γ、IFN-α2b及二者联合应用对MCF-7乳腺癌细胞增殖均有不同程度的抑制作用,二者联合应用药效作用时间延长、作用效果更佳。

Objective：To investigate the depressant effects of interferon on proliferation of MCF-7 breast cancer cells.Methods：MTT method was used to detect the depressant effects of interferon-γ（IFN-γ）,interferon-α2b（IFN-α2b） alone or combination on proliferation of MCF-7 breast cancer cells with different action times.Results：IFN-γ,IFN-α2b alone or combination all had depressant effects on proliferation of MCF-7 breast cancer cells：the depressant effects at 48h was fairly obvious when administrated the interferon alone（P〈0.05）;the depressant effects at 72h was significant when combined the interferon（P〈0.05）.Conclusions：IFN-γ,IFN-α2b alone or combination all have different depressant effects on proliferation of MCF-7 breast cancer cells.The action time is more longer and the effects is more better of combination.