摘要
目的分析乙型肝炎病毒前S1抗原与乙型肝炎病毒(HBV)血清标志物的相互关系。方法用酶联免疫吸附试验对门诊、住院患者血清进行乙型肝炎5项,前S1抗原联合检测(将检测结果中除抗-HBs阳性外的其余项中至少有一项阳性的1591例患者检测结果作回顾性分析)。结果 1591例标本检测结果中,前S1抗原主要出现在HBsAg阳性血清中,前S1抗原在HBeAg阳性组合中的检出率显著高于HBeAg阴性组合,差异有统计学意义(P<0.05),在"大三阳"组合中的检出率显著高于"小三阳"组合,差异有统计学意义(P<0.05),前S1抗原、HBeAg检出率差异有统计学意义(P<0.05)。结论前S1抗原与其他乙型肝炎表面标志物有一定的相关性,在实际工作中两种方法可协同检测,相互补充。
Objective To analyze the mutual relations between hepatitis B virus PreS1 antigen and HBV serum markers. Methods The serum of the outpatients and inpatients were detected with ELISA method,including the former S1 antigen detection （at least,one of the results from the 1591 cases besides the surface of the other items outside the anlibody positive was retrospectively analyzed）. Results From the results of 1519 cases of specimens,the PreS1 anligen was mainly found in the positive serum HBsAg,and the detection rate of portfolio in HBeAg-positive PreS1 antigen was significantly higher than that of HBeAg negative combinations （P〈0.05）. In the HbeAg positive cumbination, the delection rate was significantly higher than that in the HbeAg negative composition,with the differenee being statistically significant （P〈0.05）. The detection difference of PreS1, HBeAg was statistically significant （P〈0. 05） compred to PreSI anligen. Conclusion PreSl Antigen of hepatitis B has a certain relevance with other hepatitis B surface markers and collaborative detection is of importance in the complement with each other.
出处
《检验医学与临床》
CAS
2010年第10期937-938,940,共3页
Laboratory Medicine and Clinic
