卡维地洛治疗慢性心力衰竭的疗效观察

The effect observation of carvedilol treated with chronic heart failure

目的探讨卡维地洛对慢性心力衰竭患者的临床疗效。方法选择慢性心力衰竭患者92例,并随机分为治疗组49例和对照组43例。对照组接受常规治疗(利尿剂、血管紧张素转换酶抑制剂、洋地黄),治疗组在常规治疗的基础上加用卡维地洛。观察2组患者治疗前、治疗后6个月的心功能、左心室舒张末期容积、射血分数、6min步行距离情况。结果治疗6个月后,与对照组比较,治疗组心功能、左室舒张末期容积、射血分数及6min步行距离改善明显,差异有统计学意义(P<0.05或P<0.01)。结论卡维地洛能明显减缓慢性心力衰竭患者的病情进展,提高心力衰竭患者的运动耐量和生活质量。

Objective To evaluate the clinical therapeutic effects of carvedilol treated with chronic heart failure. Methods 92 patients with chronic heart failure were divided randomly into control group（43 cases）and treatment group（49 cases）. Control group were treated with routine therapy（turetics,ACEI or digitalis）,treatment group were treated with carvedilol in addition to routine therapy. Heart function,left ventricule diastolic dimension,ejection fraction and 6-Minute walk distance were compared between the two groups before and after six months treatment. Results After 6 months,compared with the control group,cardiac function,left ventricular end-diastolic volume,ejection fraction,and 6min walking distance of the degree of improvement of the treatment group were more obvious,the difference were statistically significant（P 0. 05 or P 0. 01）. Conclusion Carvedilol can improve the heart function obviously in the patients with chronic heart failure,and can improve exercise tolerance and quality of life in patients with heart failure.