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乌拉地尔及硝酸甘油治疗肺动脉高压的临床对比性研究 被引量:1

The comparison research of the Intravenous using of urapidil and nitroglycerin on the treatment of pulmonary hypertension
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摘要 目的探讨静脉应用乌拉地尔及硝酸甘油对慢性肺源性心脏病(肺心病)肺动脉高压的影响。方法将36例肺心病患者随机分为乌拉地尔组和硝酸甘油组,各18例。2组分别予乌拉地尔及硝酸甘油10mg溶于5%葡萄糖液250ml中缓慢静脉滴注,每天1次。治疗15d后复查。结果 2组治疗后平均肺动脉压(MPAP)均比治疗前有明显改善,差异有统计学意义(P<0.05);但在心搏指数(SI)、HR、PaO2、PaCO2方面,差异均无统计学意义(P>0.05);乌拉地尔组治疗前后平均动脉压(MAP)波动很小(P>0.05),而硝酸甘油组却有较大波动(P<0.05)。结论乌拉地尔改善肺心病肺动脉高压效果较好,血流动力学影响小,值得推荐。 Objective To learn about the effects on the treatment of pulmonary hypertension with the Intravenous u- sing of urapidil and nitroglycerin. Methods 36 patients with pulmonary hypertension were divided into the urapidil group and the nitroglycerin group,each of 18 cases. And then each group was given urapidil or nitroglycerin 10mg which was solubled in 5% GS 250ml to intravenous drip, once a day and checked the results after 15 days. Results Two guoup after treatment, mean pulmonary artery pressure(MPAP) improved significantly than that before treatment,the difference was statistically significant (P 〈 0.05) ; However, cardiac index ( SI), HR, PaO2, PaC02, the difference was statistically significant ( P 〉 0.05 ) ; In Urapidil group, mean arterial pressure (MAP) before and after treatment fluctuations in small(P 〉 0.05 ), but there was greater volatility in nitroglycerin group(P 〈 0.05). Conclusion In improving the pulmonary hypertension, urapidil was better and made little influence on the hemodynamics, and was recommended.
出处 《临床合理用药杂志》 2010年第10期5-6,共2页 Chinese Journal of Clinical Rational Drug Use
关键词 乌拉地尔 硝酸甘油 肺动脉高压 Urapidil Nitroglycerin Pulmonary hypertension
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