肾囊内注射甲基强的松龙治疗原发性肾小球肾炎临床疗效观察

The Curative Effect of Intrarenal Capsule Injection of Methylprednisolone on Primary Glomerulonephritis in 9 Patients

目的观察肾脏脂肪囊(肾囊)内注射甲基强的松龙治疗原发性肾小球肾炎的近期临床治疗效果.方法 9例肾活检证实为原发性肾小球肾炎病人,在B超引导下向每侧肾囊内注射甲基强的松龙(MP)40mg,每周2次,共10次,治疗前后观察病人的尿蛋白、血压及血清白蛋白、肌酐等变化.结果 9例病人中8例(88.9%)病人尿蛋白明显减少或转阴性,未发现糖皮质激素副作用.结论肾囊内注射甲基强的松龙为一新的治疗肾小球肾炎的方法,在有效治疗慢性肾小球肾炎的同时可避免或减少全身大剂量给药带来的毒副作用.

Objective To evaluate the short-term curative effect of intrarenal capsule injection of methylprednisolone on primary glomerulonephritis.Methods Nine patients were diagnosed as primary glomerulonephritis by renal biopsies.Under the guide of B ultrosound,40 mg methylprednisolone sodium succinate was injected into each renal adipose capsule of the patients twice a week,and each one of them was totally given ten times of the treatments.The urinary protein,blood pressure,plasma albumin,and serum creatinine were measured before and after the treatment.Result The urinary protein of 8 of 9 patients（88.9 %） had significantly been decreased,or became negative,and no obvious side effects of steroids were found.Conclusion The intrarenal adipose capsule injection therapy is an effective procedure for primary glomerulonephritis.It can not only treat chronic glomerulonephritis effectively,but also avoid or reduce the side effects of some steroids.