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膜糖蛋白CD36缺失对小鼠胰岛素抵抗的影响 被引量：2

Membrane glycoprotein CD36 deficiency promotes insulin resistance in C57BL/6 mice
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摘要 目的:研究膜糖蛋白CD36缺失对C57BL/6小鼠胰岛素抵抗(Insulin resistance,IR)的影响。方法:14周高脂饮食喂养的野生型C57BL/6小鼠和CD36基因敲除(CD36KO)小鼠,每组7只,分别进行糖耐量,胰岛素耐量和胰岛素释放试验,以及血清中甘油三酯(Triglyceride,TG)和游离脂肪酸(Free fat acid,FFA)的测定。结果:与野生型C57BL/6相比,CD36KO小鼠血糖水平增高,糖耐量实验异常,胰岛素释放曲线延迟,血清中TG((80±28.74)vs(36±18.88)mg/dl,P<0.05)和FFA((13.61±1.08)vs(0.8±0.06)mmol/L,P<0.05)水平增加。结论:CD36缺失可以促进小鼠IR。 Objective：To explore whether CD36 deficiency promotes insulin resistancein the C57BL/6 mice.Methods：Micewerefedwith a high-fat die（tn=7）for 14 weeks.Intravenous glucose tolerance tests,insulin release and tolerance tests were performed.Triglyceride and free fat acid levels in serum were measured.Results：Compared with the C57BL/6 mice,blood levels of glucose,insulin,triglyceride and free fatty acid were increased in the CD36 knockout mice.Conclusion：The CD36 deficiency indeed promotes insulin resistance in the C57BL/6 mice.
作者 陈显 柳青 雷寒 赵蕾 刘宏 陈压西 阮雄中
机构地区 重庆医科大学附属第一医院临床研究中心 重庆医科大学附属第一医院心血管内科学 重庆医科大学脂质代谢研究中心
出处 《重庆医科大学学报》 CAS CSCD 北大核心 2010年第4期485-487,共3页 Journal of Chongqing Medical University
基金 国家重点基础研究发展计划(973计划)前期研究专项(编号:2008CB517309) 国家自然科学基金项目资助(编号:30670869)
关键词 CD36 C57BL/6小鼠 CD36基因敲除小鼠 胰岛素抵抗 CD36 C57BL/6 mice CD36 knockout mice Insulin resistance
分类号 R736.6 [医药卫生—肿瘤] R730.231 [医药卫生—肿瘤]
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参考文献15

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同被引文献27

  • 1徐斌,董英,张慧慧,崔恒林,陆琪.苦瓜多糖对链脲佐菌素诱导糖尿病小鼠的降血糖效果[J].营养学报,2006,28(5):401-403. 被引量：23
  • 2宋旸,朴松兰,盛春华,常颖,金正贤,张桂珍.STZ诱导C57BL小鼠T1DM模型优化的研究[J].中国实验诊断学,2007,11(1):36-39. 被引量：7
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  • 6Cunha JM, Funez FQ, Parada CA, et al. Streptozotocin-induced mechanical hypernociception is not dependent on hyperglycemia[J]. Brazil J Me Biol Res, 2009, 42:197-206.
  • 7Kim JO, Lee GD, Kwon JH, et al. Anti-diabetic effects of new herbal formula in neonatally streptozotocin-induced diabetic rats [J].Biol Pharm Bull, 2009, 32(3): 421-426.
  • 8He Y, Martinez-Fleites C, Bubb A, et al. Structural insight into themechanism of streptozotocin inhibition ofO-GlcNA-case [J]. CarbohydrRes, 2009, 344(5): 627-631.
  • 9Pathak S, Dorfinueller HC, Borodkin VS, et al. Chemical dissection of the link between streptozotocin, O-GlcNAc,and pancreatic cell death [J]. Chem Biol, 2008, 15(8): 799-807.
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重庆医科大学学报
2010年 第4期

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