心血管危险因素与重庆地区冠状动脉疾病的相关性分析

Study on the relationship between cardiovascular risk factors and coronary artery disease

目的:分析传统的心血管危险因素与重庆地区冠状动脉疾病的关系。方法:对疑诊或者已经确诊的398例冠心病患经询问病史,体格检查,生化检查后;进行选择性冠状动脉造影,据其结果分为3组:冠心病(Coronary heart disease,CHD)组(例)、冠状动脉粥样硬化(Coronary arteriosclerosis,CAS)组(44例)和对照(Control,CT)组(128例)。分析比较各组危险因素的率,并用单因素和多因素logistic回归分析方法分别研究危险因素与CHD和CAS的关系。结果:(1)与CT组比较,除体重指外,CHD组患高血压病、2型糖尿病、高脂血症、有吸烟及心血管病家族史比例明显增高(P<0.05,多数P<0.01),男性更容易患心病(P<0.05);CAS组患高血压病和有心血管病家族史比例明显增高(P<0.05),其余各危险因素无显著差异。CHD组与CAS组组间相比较,各项危险因素之间无显著性差异(P>0.05)。(2)CHD组与CAS组两组间的心血管危险因素分布无明显差异(P>0.0(3)心血管危险因素越多,越容易发生冠状动脉疾病。结论:除体重指数外,传统的心血管危险因素与本地区的冠心病明显相是冠状动脉疾病发生发展的重要而独立的危险因素。

Objective：To analyze the relationship between conventional cardiovascular risk factors and coronary artery disease in Chongqing area.Methods：Three hundreds and ninety-eight patients were enrolled with a medical history in detail,a physical examination and biochemistry examination,who were diagnosed or suspected were performed by coronary angiography（CAG）,then these patients were divided into three groups according to the result of CAG,coronary heart disease（CHD）group（226 cases）,coronary arteriosclerosis（CAS）group（44 cases）and control group（CT）（128 cases）.Toanalyze and compare the ratioofrisk factors in each group,univariate and multivariate logistic regression method were used respectively to analyze the relationship between risk factors and CHD or CAS group.Results：1.Compared with CT group,the percentage of hypertensive（HP）,type 2 diabetes mellitus（T2DM）,hyperlipidemia,smoking history and family history of cardiovascular disease was significantly higher in CHD group（P〈0.05,more P〈0.01）.Men were more likely to suffer from CHD than women（P〈0.05）.There was no significant difference of body mass index（BMI）for these two groups.Compared with CT group,the percentage of HP and family history of cardiovascular disease was higher significantly in CAS group（P〈0.05）.But there was no significant difference with the other cardiovascular risk factors.There was no significant difference with the percentage of each risk factor between CHD group and CAS group（P〉0.05）.2.The distribution of risk factors in CHD group was the same as CAS group（P〉0.05）.3.The more cardiovascular risk factors,the more serious coronary artery disease.Conclusion：Besides BMI,conventional risk factors of cardiovascular contribute to coronary heart disease in this area,and they play an important and independent role in occurrence and progression of coronary artery disease.