ApoB/ApoA1比值与胰岛素抵抗的相关性研究

Study of association between ApoB/ApoA1 ratio and insulin resistance

目的:探讨载脂蛋白B(ApoB)/载脂蛋白A1(ApoA1)比值与胰岛素抵抗(Insulin Resistance,IR)的关系。方法:纳入673例重庆地区成年人,测定体重、身高、血压、腰围、空腹血浆葡萄糖(Fastingplasma glucose,FPG)、空腹血清胰岛素(Fasting serum insulin,FINS)及血脂等,计算ApoB/ApoA1比值、体重指数(Bodymassindex,BMI)及胰岛素抵抗指数(Homa-IR)。根据ApoB/ApoA1的四分位值将人群分为4组,用Logistic回归分析ApoB/ApoA1值与IR的关系。结果:与非胰岛素抵抗(Non-insulinresistance)者相比,IR人群的年龄、BMI、收缩压、舒张压、FPG、FINS、TG、LDL-c水平及ApoB/ApoA1比值均显著增高,而HDL-c水平降低(P<0.05);随ApoB/ApoA1值增高,HomaIR值逐渐增高(P<0.001);ApoB/ApoA1值最高组(上四分位组)发生IR的风险是最低组(下四分位组)的2.586倍(P=0.001)。结论:ApoB/ApoA1比值与IR密切相关,ApoB/ApoA1比值增高是IR发生的重要标志。

Objective：To assess if the ratio of ApoB/ApoA1 is related to insulin resistance.Methods：673 adults living in Chongqing were enrolled.Weight,height,blood pressure,waist circumferences,fasting plasma glucose（FPG）,fasting serum insulin（FINS）and lipids were measured.ApoB/ApoA1 ratio,BMI and insulin resistance index（Homa-IR）were calculated.Subjects were divided into four groups according to the quartiles of ApoB/ApoA1 ratio.Logistic regression was used to estimate the relation between ApoB/ApoA1 ratio and insulin resistance.Results：Compared with the non-insulin resistant group,the insulin resistant group is older and has on average greater mean values for BMI,systolic and diastolic blood pressure,fasting plasma glucose,triglycerides,LDL-cholesterol,and ApoB/ApoA1 ratio.In contrast,insulin resistant subjects has significantly lower HDL-cholesterol than insulin sensitive subjects（P〈0.05）.Homeostasis model assessment increased significantly as ApoB/ApoA1 ratio increased（P〈0.001）.Compared with the lowest quartile of ApoB/ApoA1 ratio,the highest quartile of ApoB/ApoA1 ratio is more likely to get IR,and the risk increased 2.586 times（P=0.001）.Conclusion：ApoB/ApoA1 ratio is strongly associated with insulin resistance（IR）,and a high ApoB/ApoA1 ratio is a valuable marker of IR.