血液灌流1次与2次治疗慢性肝炎高胆红素患者的疗效比较

The therapeutic effects comparison between one and two hemoperfusion in treatment of chronic hepatitis with hyperbilirubinemia

目的:探讨利用血液灌流(Hemoperfusion,HP)1次和2次治疗慢性肝炎高胆红素患者的临床疗效。方法:采用回顾性分析方法,收集27例血液灌流1次和41例血液灌流2次的慢性肝炎高胆红素患者的临床资料,观察并对比分析组之间治疗前后肝功能、凝血酶原时间、生化等指标。结果:HP2组与HP1组对比分析得出,HP2组较HP1组患者胆红素和转氨酶有明显的降低(P<0.05),但红细胞和血红蛋白也有显著降低(P<0.05),其余各指标两组间无明显差异(P>0.05);2组的血钾均有明显的升高。结论:2次HP更能有效吸附和降低慢性肝炎患者体内的胆红素和转氨酶,是治疗高胆红素血症患者的有效手段。

Objective：To investigate the clinical efficacy between one and two hemoperfusion in treatment of chronic hepatitis with hyperbilirubinemia.Methods：The clinical data of 68 chronic hepatitis patients with hyperbilirubinemia were reviewed restropectively.27 patients were treated with one hemoperfusion（HP1）and 41 patients were treated with two hemoperfusion（HP2）.The liver function,prothrombin time activity,biochemical indicators before and after hemoperfusion in the two groups were compared and analyzed.Results：After two hemoperfusion treatment.,Compared with HP1,the levels of bilirubin and transaminase were decreased significantly（P〈0.05）but the erythrocyte and hemoglobin were also decreased significantly（P〈0.05）in HP2 treatment group（434.44± 163.28）v（s480.48±168.31）,（104.85±142.85）v（s176.77±132.61）,（3.30±0.58）v（s3.58±0.48）,（95.49±15.31）v（s108.93± 15.66）,other indicators had no significanc（P〈0.05）.Conclusions：Two hemoperfusion treatment can more effectively make bilirubin and transaminase removed from patients of chronic hepatitis with hyperbilirubinemia,so two hemoperfusion was safe and effective treatment for patients with hyperbilirubinemia.