MECT合并SSRIs类药物与单用SSRIs类药物治疗中重度抑郁症的对照研究

A comprative study of MECT combined SSRIs therapy and single SSRIs therapy in the treatment of moderate-severe depression

目的:探讨无抽搐电休克(Modified electroconvulsive therapy,MECT)合并SSRIs类药物与单用SSRIs类药物治疗中重度抑郁症的疗效效果。方法:将150例中重度抑郁症患者随机分为MECT合并SSRIs组(研究组)75例和单用SSRIs类药物组(对照组)75例,分别在治疗前、第1周、第2周、第4周、第6周后,完成汉密尔顿抑郁量表(Hamilton depression scale,HAMD)用以评估症状及疗效。结果:根据HAMD评分,MECT合并SSRIs组分别在第1、2、4、6周后评分明显小于单用药物组(P<0.01)。MECT合并SSRIs组在第6周后显效,有效率均明显高于单用药物组(P<0.05)。结论:在治疗中重度抑郁症时,临床医生可更多地考虑选用MECT合并SSRIs治疗方案。

Objective：To compare the efficacy between MECT combined SSRIs therapy and single SSRIs therapy in the treatment of moderate-severe Depression.Methods：150 patients with moderate-severe depression were random divided into group of MECT combined SSRIs therapy and single SSRIs therapy group.The clinical efficacy were assessed by Hamilton Depression Rating Scale（HAMD）for five time（sbefore therapy,on first,second,fourth,sixth weekend）.Results：Comparing the research group to the controlled group the effect was obviously better on first;second,fourth and sixth weekend according to HAMD scores decreasing（P〈0.01）.The research group presented effect on the 6th weekend,which gained a significant improvement rate and efficient rate of MECT（P〈0.05）.Concusion：The clinicians may choose the effective MECT combined SSRIs therapy as a way of treating moderate-severe depression.