1648例孕中期母血清产前筛查结果分析

Analysis of prenatal screening 1648 cases in mid-pregnant women

目的:评估血清标志物甲胎蛋白(Alpha-fetoprotein,AFP)和游离绒毛膜促性腺激素(Free-βHCG)在孕中期进行先天缺陷疾病筛查的价值和作用。方法:用酶联免疫法对孕妇血清AFP和free-βHCG进行检测,并结合孕妇年龄、孕周、体重等因素,采用配套软件估算风险概率。结果:在3299例孕中期妇女中,唐氏综合征、18-三体综合征和神经管缺陷高危筛查阳性率分别为7.16%、0.61%和2.37%。经细胞遗传学分析1例确诊为唐氏综合征,另外2例经超声检查证实为神经管缺陷。结论:孕中期母血清二联(AFP,free-βHCG)检查是有效安全的产前筛查方法,有利于降低先天性缺陷婴儿的出生率。

Objective：To assess the value and impact of screening programme in mid-pregnancy women for the congenital fet abnormality that uses the two maternal serum markers：α-fetoprotein（AFP）and freeβhuman chorionic gonadotrophin（free-βHCG） Methods：Serum screening of AFP and free-βHCG were offered to the 14～20 weeks pregnant Measuring the serum AFP and free βHCGin pregnant women with ELISA,and combined with other factors：age,weeks of pregnancy,weight,etc.Measuring the high ri rate with special software.Results：Within 1 648 cases of women in the mid-pregnancy,Down＇s syndrom,18-trisomysyndrome an neural tube defect high risk rates in screen were 7.16%,0.61%and 2.37%respectively.1 case was confirm the Down＇s syndrome analysis of cytogenetics,another 2 cases was diagnosed neural tube defect via ultrasonography.Conclusion：the second trimester doub test would be effective and safe screening strategies and could be used to decrease natality of congenital fetal malformation