重庆市8～10岁儿童不同时段尿碘变化规律

Study on the rhythm of urine iodine level of children aged 8-10 in Chongqing city

目的 了解重庆市8～10岁儿童不同时段尿碘变化规律.方法 2008年4月,采用分层随机抽样方法抽取重庆市区一所住宿小学的8～10岁学龄儿童60名（每个年龄组20名,男女各半）,集中一天采集晨尿、10：00、12：30、16：00尿样,采用砷铈催化分光光度法（WS/T 107-2006）检测尿碘.对儿童不同年龄、性别、时段尿碘进行比较分析.结果 60名儿童4个时段总体尿碘中位数为265.07μg/L.不考虑各分层因素的影响,除晨尿（366.75μg/L）与10：00尿（338.30 μg/L）之间、12：30尿（235.15μg/L）与16：00尿（251.50 μg/L）之间尿碘比较差异无统计学意义（P均〉0.05）外,其他时段两两比较差异有统计学意义（P均〈0.05）.8岁组尿碘除晨尿（298.90μg/L）与10：00、16：00尿（279.00、286.59μg/L）之间及10：00尿与16：00尿之间比较差异无统计学意义（P均〉0.05）外,其他时段两两比较差异有统计学意义（P均〈0.05）;9岁组尿碘除晨尿（366.15μg/L）与10：00尿（368.10μg/L）之间、12：30尿（244.00 μg/L）与16：00尿（186.30 μg/L）之间比较差异无统计学意义（P均〉0.05）外,其他时段两两比较差异有统计学意义（P均〈0.05）;10岁组尿碘在12：30之前（382.85、449.60、337.00 μg/L）变化不大（P均〉0.05）,之后急速下降,到16：00时（269.35μg/L）与晨尿及10：00尿之间比较差异有统计学意义（P均〈0.05）.不论男生还是女生,除晨尿（337.32、309.28 μg/L）与10：00尿（316.15、288.27μg/L）之间、12：30尿（251.18、211.45μg/L）与16：00尿（235.02、211.45μg/L）之间尿碘比较差异无统计学意义（P均〉0.05）外,其他时段两两比较差异有统计学意义（P均〈0.05）.结论 8～10岁儿童上午尿碘值变动不明显,下午变动较大,用10：00之前尿样代替晨尿具有代表性和可行性.

Objective To undemtand the rhythm of urinary iodine level of children aged 8-10 in Chongqing city.Methods In April 2008,using the stratified random sampling method,we sampled 60 children aged 8-10 in a lodging primary school in Chongqing（20 per age group,half male and half female）,the urine samples were collected in the morning and at 10：00,12：30,16：00,iodine in urine was detected by method of Ce and arsenic catalytic speetrophotometry（WS/T 107-2006）.The difference of the urinary iodine level was compared by age,sex and time of day.Results The median urinary iodine of 60 children was 265.07μg/L on the overall.Irrespective of the stratification factors,excluding morning urinary iodine（366.75μg/L）and urinary iodine at 10：00（338.30 μg/L）,the urinary iodine between 12：30（235.15μg/L）and 16：00（251.50μg/L）was not significant（all P〉0.05）,statistically significant differences（all P〈0.05）were found between any two.The urinary iodine of 8-year-old group at different times of the day was significantly different（all P〈0.05）,except between morning urinary iodine （298.90 μg/L）and at 10：00,16：00（279.00,286.59 μg/L）,between urinary iodine at 10：00 and 16：00（all P〉0.05）.The 9-year-old group＇s urinary iodine were not significantly different between morning urine（366.15μg/L）and 10：00（368.10 μg/L）,and between 12：30（244.00 μg/L）and 16：00（186.30 μg/L,all P〉0.05）,significant differences were faund at other times of the day（all P〈0.05）.The 10-year-old group of urinary iodine changed very little before 12：30 （382.85,449.60,337.00 μg/L, all P 〉 0.05 ）, followed by rapid decline to 16： 00 （269.35 μg/L）, and compared with the morning urine and 10：00, there was significant difference（all P 〈 0.05）.Regardless boys or girls, the urinary iodine at different times qf the day was significantly different （all P 〈 0.05）,except between morning urinary iodine（337.32,309.28 μg/L） and at 10：00（316.15,288.27 μg/L）, between urinary iodine at 12：30（251.18,211.45 μg/L） and 16：00（235.02,211.45 μg/L, all P 〉 0.05）. Conclusions The change of urinary iodine level in children aged 8 - 10 was not obvious before noon, changes can be seen in the afternoon.Urinary iodine level before 10：00 is indicative.