保留肝容积率CT评估肝癌介入治疗肝储备功能研究

Study on function of liver retention volume ratio in evaluation of liver retention in hepatic carcinoma interventional therapy

目的探讨CT测量保留肝容积率对评估肝癌介入治疗前肝储备功能与预后的价值。方法前瞻性收集2005年～2008年行经导管栓塞化疗(TACE)治疗的60例原发性肝癌病人术前术后信息,所有病人术前均采用双期增强CT扫描,测量CT保留肝容积率,与术后肝功能生化指标变化及生存时间对照研究。结果介入保留肝容积率与肝功能谷草转氨酶(AST)变化率呈中度相关(r=-0.516,P<0.05),与肝功能谷丙转氨酶(ALT)变化率呈轻度相关(r=-0.331,P<0.05);介入保留肝容积率<50%组和≥50%组的中位生存时间分别为8.2和59.0个月,两组间生存时间差异显著,有统计学意义(x^2=15.9,P<0.0001)。结论 CT测量保留肝容积率对肝癌介入治疗肝储备功能与预后有一定的评估价值。

Objective To investigate the clinical value of liver CT retention rate of liver volume in patients with primary liver cancer. Methods Prospectively collecting the informations of 60 patients in primary liver cancer with transcatheter arterial chemoembolization （TACE）between 2005-2008, all patients were preoperatively scaned with dual-phase enhancement CT. The liver volume rates of retention, the postoperative changes of biochemical markers of liver function and survival time-control were measured. Results The correlation coefficient of retention rate of liver volume with liver function in aspartate aminotransferase （AST） rate of change was -0.516 （P〈 0.05）. The correlation coefficient of the rate with the liver function in alanine aminotransferase （ALT）was -0.331 （P 〈 0.05）. The median survival time was respectively 8.2 months and 59.0 months in the group of the retention rate of liver volume 〈50% and the group of ≥ 50%.There are significant deviation in survival time between the two groups, with statistical significance（χ^2=15.9, P〈 0.0001）. Conclusion The retention rate of CT liver volume is of certain value in evaluation of prognosis in patients with TACE therapy of hepatocellular carcinoma.