细胞因子信号转导抑制物与糖尿病

Suppressors of cytokine signaling proteins and diabetes mellitus

细胞因子在糖尿病发病中的作用逐渐受到人们的重视。细胞因子信号转导抑制物(suppressors of cytokine signaling,SOCS)可抑制细胞因子在细胞内的信号转导,并对糖尿病的发病和发展起着一定的促进作用。此外,SOCS蛋白也参与胰岛素抵抗和瘦素抵抗的发生和发展。

Cytokines plays an important role in the pathogenesis of diabetes mellitus.The suppressors of cytokine signaling（SOCS） proteins can inhibit the cytokine signaling pathway,and contribute to the pathogenesis and development of diabetes mellitus.In addition,it has been proved that SOCS can induce both insulin and leptin resistance.