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阿托伐他汀对大脑中动脉支架置入后血脂及C-反应蛋白的影响

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摘要 目的观察阿托伐他汀对大脑中动脉支架置入后患者血脂、血清C-反应蛋白(CRP)及脑缺血性不良事件的影响。方法将成功完成大脑中动脉支架置入术的24例患者按随机数字表随机分为2组,每组12例。治疗组口服阿托伐他汀+硫酸氢氯吡格雷+拜阿司匹林,对照组口服硫酸氢氯吡格雷+拜阿司匹林。术后1月、3月、6月、12月比较观察两组血清CRP、血脂的变化及主要的脑缺血性不良事件的发生情况。结果与对照组比较,治疗组术后血脂及CRP水平明显下降(P<0.05),脑缺血性不良事件的发生率明显降低(P<0.05);治疗组术后血脂及血清CRP水平较术前明显降低(P<0.05)。结论阿托伐他汀能通过抑制炎性反应的发生,调脂、稳定斑块,可有效预防支架置入后脑缺血性不良事件的发生。
出处 《中国临床神经外科杂志》 2010年第5期295-297,共3页 Chinese Journal of Clinical Neurosurgery
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参考文献10

  • 1贺雄军,缪中荣,凌锋,华扬,李慎茂,朱凤水,吉训明,焦力群.症状性大脑中动脉狭窄患者支架置入术后再狭窄影响因素的分析[J].中国脑血管病杂志,2008,5(1):5-9. 被引量:25
  • 2Azar RR,McKay RG,Kiernan FJ,et al.Coronary angioplasty induces a systemic inflammatory response[J].Am J Cardio1,1997,80(11):1476-1478.
  • 3张旭,江秀龙,雷惠新.脑梗死患者血清超敏C反应蛋白检测及临床意义[J].疑难病杂志,2008,7(2):71-73. 被引量:27
  • 4Hashimoto H,Kitagawa K,Hougaku H,et al.Relationship between C-reactive protein and progression of early carotidatherosclerosis in hypertensive subjects[J].Stroke,2004,35(7):1625-1630.
  • 5Wang TJ,Nam BH,Wilson PW,et al.Association of C-reactive protein with carotid atherosclerosis in men and women:the Framingham Heart Study[J].Arterioscler Thromb Vasc Biol,2002,22(10):1662-1667.
  • 6Versaci F,Gaspardone A,Tomai F,et al.Immunosuppressive therapy for the prevention of restenosis after coronary artery stent implantation (Impress Study)[J].J Am Coll Cardiol,2002,40(11):1935-1942.
  • 7Kasner SE,Chimowitz MI,Lynn MJ,et al.Predictors of ischemic stroke in the territory of a symptomatic intracranial arterial stenosis[J].Circulation,2006,113(4):555-563.
  • 8Amarenco P.Atorvastatin in prevention of stroke and transient ischaemic attack[J].Exp Opin Pharm,2007,8(16):2789-2797.
  • 9Amarenco P,Goldstein LB,Szarek M,et al.Effects of intense low-density lipoprotein cholesterol reduction in patients with stroke or transient ischemic attack:the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial[J].Stroke,2007,38(12):3198-3204.
  • 10Castilla Guerra L,Del Carmen Fernandez Moreno M,Lopez Chozas JM,et al.Statins in stroke prevention:What an internist should know[J].Eur J Intern Med,2008,19(1):8-14.

二级参考文献23

  • 1李辉,王兆宏.血清C反应蛋白在急性脑梗死患者临床评估中的价值[J].疑难病杂志,2006,5(2):97-99. 被引量:12
  • 2各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量:33024
  • 3[1]Sacco RI,Kargman DE,Gu Q,et al.Race-ethnicity and determinants of intracranial atherosclerotic cerebral infarction.The Northern Manhattan Stroke Study[J].Stroke,1995,26:14-20.
  • 4[2]Wityk RJ,Lehman D,Klag M,et al.Race and sex differences in the distribution of cerebral atherosclerosis[J].Stroke,1996,27:1274-1980.
  • 5[3]Wholey MH,Wholey M,Mathias K,et al.Global experience in cervical carotid artery stent placement[J].Catheter Cardiovasc Interv,2000,50:160-167.
  • 6[4]Ohki T,Marin ML,Lyon RT,et al.Ex vivo human carotid artery bifurcation stenting:correlation of lesion characteristics with embolic potential[J].J Vasc Surg,1998,27:463-471.
  • 7[5]Food and Drug Administration.Wingspan stent system and gateway PTA balloon catheter:summary of safety and probable benefit (EB/OL)].(2005-08-03).http://www.fda.gov/cdrh/pdf5/h050001 b.pdf.
  • 8[6]The SSYLVIA Study Investigations.Stenting of Symptomatic Atherosclerotic Lesions in the Vertebral or Intracranial arteries(SSYLVIA):study result[J].Stroke,2004,35:1388-1392.
  • 9[7]Rishi G,Firas AA,Ajith J,et al.Safety,feasibility,and short-term follow-up of drug-eluting stent placement in the intracranial and extracranial circulation[J].Stroke,2006,37:2562-2566.
  • 10[8]Alex AC,Qasim B,Jay S,et al.Drug-eluting stents for treatment of intracranial atherosclerosis[J].Stroke,2005,36:165-168.

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