期刊文献+

原发性高血压合并无症状性腔隙性脑梗死危险因素的研究 被引量:3

Risk factors for essential hypertension complicating silent lacunar infarction
下载PDF
导出
摘要 目的探讨原发性高血压患者合并无症状性腔隙性脑梗死(SLCI)的危险因素。方法选择原发性高血压患者111例,按照是否同时存在SLCI,分为SLCI组(37例)和对照组(74例)。收集患者的生化检测指标、尿微量白蛋白(MAU)、腰臀比(WHR)、体质量指数(BMI)、高血压病程/血压分级以及是否存在吸烟、糖尿病、冠心病史等危险因素。结果①与对照组比较,SLCI组患者的三酰甘油[M(QR):1.7(1.4)mmol/L、1.5(1.1)mmol/L]、尿微量蛋白[27.5(11.0)mg/24 h、7.0(5.5)mg/24 h]、超敏C反应蛋白[1.3(0.8)mg/L、1.0(0.4)mg/L]、红细胞体积分布宽度[(12.5±0.7)、(12.2±0.6)]、腰臀比[(0.94±0.08)、(0.88±0.09)]、体质量指数[(27±13)kg/m^2、(25±3)kg/m^2]均高于对照组,差异有统计学意义,P<0.05;②Logistic多元回归分析显示,尿微量的蛋白(OR:1.482;95%CI:1.067~2.060)、红细胞体积分布宽度(OR:12.599;95%CI:1.164~136.358)、糖尿病(OR:2.528;95%CI:1.105~5.783)是本研究中高血压合并SLCI的独立危险因素。结论原发性高血压合并SLCI患者的尿微量白蛋白、红细胞体积分布宽度明显增加,是高血压合并SLCI的独立危险因素。 Objective To investigate the risk tactors for essential hypertensive patients complicating silent lacunar infarction (SLI). Methods A total of 111 patients with essential hypertension were recruited in the study. They were divided into SLI group and control group according to whether they had SLI. The bio- chemical detection index, mieroalbuminuria (MAU), waist to hip ratio (WHR), body mass index (BMI), duration of hypertension and blood pressure grade of the patients, as well as whether they had the following risk factors, such as history of smoking, drinking, diabetes, and coronary heart disease, were collected. Results (1)Triglyceride (M [ QR ] : 1.7 [ 1. 4 ] mmol/L vs. 1.5 [ 1. 1 ] mmol/L), microalbuminuria ( 27.5 [ 11.0 ] mg/24 h vs. 7.0 [ 5.5 ] mg/24 h), high sensitivity C-reactive protein ( 1.3 [0. 8 ] mg/L vs. 1.0 [ 0.4 ] mg/L), red blood cell volume distribution width ( 12. 5 ±0. 7 vs. 12. 2± 0. 6), WHR (0. 94 ± 0. 08 vs. 0. 88 ±0.09), and BMI (27 ± 13 kg/m2 vs. 25 ±3 kg/m2) in the SLI group were significantly higher than those in the control group. There were significant differences between the two groups ( P 〈 0.05 ). (2)A Mul- tiple Logistic regression analysis showed that MAU, red cell volume distribution width( RDW), and diabetes mellitus were the independent risk factors for hypertension complicating SLI in this study. Conclusion The significantly increased MAU and RDW in patients with essential hypertension complicating SLI are the inde- pendent risk factors for hypertension complicating SLI. Using MAU and RDW determination to evaluate the risk for hypertensive patients complicating lacunar infarction have important significance.
出处 《中国脑血管病杂志》 CAS 2010年第5期241-244,共4页 Chinese Journal of Cerebrovascular Diseases
基金 北京市自然科学基金资助项目(7072032)
关键词 高血压 脑梗死 白蛋白尿 红细胞体积分布宽度 Hypertension Brain infarction Albuminuria Red cell volume distribution width
  • 引文网络
  • 相关文献

参考文献15

  • 1Iadecola C,Davisson RL.Hypertension and cerebrovascular dysfunction[J].Cell Metab,2008,7(6):476-484.
  • 2各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量:33053
  • 3Koziolek MJ,Bramlage CP,Vasko R,et al Microalbuminuria and albuminuria:differential diagnosis and consequences for treatment[J].Dtsch Med Wochenschr,2009,134(34):1681-1685.
  • 4Roquer J,Segura T,Serena J,et al.Endothelial dysfunction,vascular disease and stroke:the ARTICO study[J].Cerebrovasc Dis,2009,27(1):25-37.
  • 5Henskens LH,van Oostenbrugge RJ,Kroon AA,et al.Detection of silent cerebrovascular disease refines risk stratification of hypertensive patients[J].J Hypertens,2009,27(4):846-853.
  • 6Tebbe U,Bramlage P,Thoenes M,et al.Prevalence of microalbuminuria and its associated cardiovascular risk:German and Swiss results of the recent global i-SEARCH survey[J].Swiss Med Wkly,2009,139(33):473-480.
  • 7Dabbah S,Hammerman H,Markiewicz W,et al.Relation between red cell distribution width and clinical outcomes after acute myocardial infarction[J].Am J Cardiol,2010,105(3):312-317.
  • 8Lippi G,Targher G,Montagnana M,et al Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients[J].Arch Pathol Lab Med,2009,133(4):628-632.
  • 9Hitha B,Pappachan JM,Pillai HB,et al.Microalbuminuria in patients with essential hypertension and its relationship to target organ damage:an Indian experience[J].Saudi J Kidney Dis Transpl,2008,19(3):411-419.
  • 10Choudhary N,Ahlawat RS.Interleukin-6 and C-reactive protein in pathogenesis of diabetic nephropathy:new evidence linking inflammation,glycemic control,and microalbuminuria[J].Iran J Kidney Dis,2008,2(2):72-79.

共引文献33052

同被引文献55

引证文献3

二级引证文献18

;
使用帮助 返回顶部