摘要
目的探讨原发性高血压患者合并无症状性腔隙性脑梗死(SLCI)的危险因素。方法选择原发性高血压患者111例,按照是否同时存在SLCI,分为SLCI组(37例)和对照组(74例)。收集患者的生化检测指标、尿微量白蛋白(MAU)、腰臀比(WHR)、体质量指数(BMI)、高血压病程/血压分级以及是否存在吸烟、糖尿病、冠心病史等危险因素。结果①与对照组比较,SLCI组患者的三酰甘油[M(QR):1.7(1.4)mmol/L、1.5(1.1)mmol/L]、尿微量蛋白[27.5(11.0)mg/24 h、7.0(5.5)mg/24 h]、超敏C反应蛋白[1.3(0.8)mg/L、1.0(0.4)mg/L]、红细胞体积分布宽度[(12.5±0.7)、(12.2±0.6)]、腰臀比[(0.94±0.08)、(0.88±0.09)]、体质量指数[(27±13)kg/m^2、(25±3)kg/m^2]均高于对照组,差异有统计学意义,P<0.05;②Logistic多元回归分析显示,尿微量的蛋白(OR:1.482;95%CI:1.067~2.060)、红细胞体积分布宽度(OR:12.599;95%CI:1.164~136.358)、糖尿病(OR:2.528;95%CI:1.105~5.783)是本研究中高血压合并SLCI的独立危险因素。结论原发性高血压合并SLCI患者的尿微量白蛋白、红细胞体积分布宽度明显增加,是高血压合并SLCI的独立危险因素。
Objective To investigate the risk tactors for essential hypertensive patients complicating silent lacunar infarction (SLI). Methods A total of 111 patients with essential hypertension were recruited in the study. They were divided into SLI group and control group according to whether they had SLI. The bio- chemical detection index, mieroalbuminuria (MAU), waist to hip ratio (WHR), body mass index (BMI), duration of hypertension and blood pressure grade of the patients, as well as whether they had the following risk factors, such as history of smoking, drinking, diabetes, and coronary heart disease, were collected. Results (1)Triglyceride (M [ QR ] : 1.7 [ 1. 4 ] mmol/L vs. 1.5 [ 1. 1 ] mmol/L), microalbuminuria ( 27.5 [ 11.0 ] mg/24 h vs. 7.0 [ 5.5 ] mg/24 h), high sensitivity C-reactive protein ( 1.3 [0. 8 ] mg/L vs. 1.0 [ 0.4 ] mg/L), red blood cell volume distribution width ( 12. 5 ±0. 7 vs. 12. 2± 0. 6), WHR (0. 94 ± 0. 08 vs. 0. 88 ±0.09), and BMI (27 ± 13 kg/m2 vs. 25 ±3 kg/m2) in the SLI group were significantly higher than those in the control group. There were significant differences between the two groups ( P 〈 0.05 ). (2)A Mul- tiple Logistic regression analysis showed that MAU, red cell volume distribution width( RDW), and diabetes mellitus were the independent risk factors for hypertension complicating SLI in this study. Conclusion The significantly increased MAU and RDW in patients with essential hypertension complicating SLI are the inde- pendent risk factors for hypertension complicating SLI. Using MAU and RDW determination to evaluate the risk for hypertensive patients complicating lacunar infarction have important significance.
出处
《中国脑血管病杂志》
CAS
2010年第5期241-244,共4页
Chinese Journal of Cerebrovascular Diseases
基金
北京市自然科学基金资助项目(7072032)
关键词
高血压
脑梗死
白蛋白尿
红细胞体积分布宽度
Hypertension
Brain infarction
Albuminuria
Red cell volume distribution width