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单核细胞源性泡沫细胞TREM-1的表达 被引量：1

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摘要 目的探讨髓系细胞触发受体-1(TREM-1)在氧化型低密度脂蛋白胆固醇(ox-LDL)诱导的巨噬细胞源性泡沫细胞中的表达情况。方法先后用PMA、ox-LDL诱导人U937细胞,使其转化为泡沫细胞。用RT-PCR法及Western印迹法检测PMA诱导组、低密度脂蛋白(LDL)组和ox-LDL组细胞中TREM-1 mRNA及蛋白的表达。结果与PMA诱导组、PMA+LDL组细胞比较,PMA+ox-LDL组细胞TREM-1 mRNA及蛋白表达水平均明显增高(P<0.05)。结论TREM-1可能参与泡沫细胞的形成,与动脉粥样硬化(AS)斑块的发生发展密切相关,可能成为AS治疗的一个新的靶点或监测AS进展的一项新指标。
作者 王宇石 刘心刚
机构地区 吉林大学第一医院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2010年第9期1247-1249,共3页 Chinese Journal of Gerontology
关键词 泡沫细胞 髓系细胞触发受体-1 动脉粥样硬化
分类号 Q5 [生物学—生物化学]
  • 相关文献

参考文献7

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共引文献44

同被引文献22

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中国老年学杂志
2010年 第9期

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