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肾脏转运蛋白的分类及其在抗生素肾脏清除的作用

Classification of renal transporters and their roles on the renal clearance of antibiotics
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摘要 大多数抗生素在体内通过肾脏排泄清除,而这一过程主要是通过肾小管表达的多种转运蛋白所产生的分泌作用实现的。本文对肾脏转运蛋白的分类、种属差异、以及可能产生的与抗生素有关的药物间相互作用进行综述。 Most of the antibiotics are eliminated by kidney, and this process mainly depends on renal tubular secretion through the function of renal transporters. This review focuses on the classification of renal transporters, species differences, and the possible drug- drug interactions caused by renal transporters.
作者 邵克花 张莉 魏敏吉
机构地区 北京大学第一医院临床药理研究所
出处 《中国临床药理学杂志》 CAS CSCD 北大核心 2010年第5期391-394,共4页 The Chinese Journal of Clinical Pharmacology
关键词 肾脏清除 转运蛋白 抗生素 renal clearance transporters antibiotics
分类号 R978.1 [医药卫生—药品] R969.1 [医药卫生—药理学]
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参考文献20

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中国临床药理学杂志
2010年 第5期

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