川芎嗪抑制肝纤维化作用机制的研究进展

Progress in effects mechanism of tetramethylpyrazine in the treatment of hepatic fibrosis

肝脏慢性损伤,包括病毒性肝炎、酗酒、药物作用及代谢性疾病等,均可导致肝纤维化。肝纤维化是一个可逆过程,病程进展导致的肝硬化是不可逆的,因此在纤维化早期进行及时诊断及有效的治疗,可减缓或防止发展为肝硬化。近年来研究发现,中药川芎中的有效成分(川芎嗪)在治疗肝纤维化中发挥了较好的治疗效果,本文对川芎嗪治疗肝纤维化的作用机制进行综述。

Chronic liver injury, including viral hepatitis, alcoholism, drugs and metabolic diseases, lead to hepatic fibrosis. Hepatic fibrosis is a reversible process, but liver cirrhosis resulted from progress of hepatic fibrosis is not reversible. Thus, early diagnosis in the fibrosis stage and timely effective treatment can slow or prevent the development of liver cirrhosis. In recent years, tetramethylpyrazine , an active ingredients in Chuanxiong has played good therapeutic effect in the treatment of hepatic fibrosis. This paper reviewed the effect and mechanism of tetramethylpyrazine in the treatment of hepatic fibrosis.