长托宁治疗急性有机磷中毒疗效观察

Observation of therapeutic effect of penehyclidine hydrochloride on acute organophosphorus pesticide poisoning

目的:观察长托宁(盐酸戊乙奎醚)代替阿托品救治有机磷中毒的效果。方法:将133例急性有机磷中毒患者间隔法分为两组:长托宁组67例使用长托宁,阿托品组66例使用阿托品。对于中、重度中毒者均配用氯磷定进行治疗。对其疗效和不良反应进行对照和统计学处理。结果:两组患者在治愈率、疗效、不良反应、病死率存在明显差异(P<0.05)。结论:有机磷中毒患者应用长托宁治疗较阿托品治疗效果更好,长托宁是比较理想的新型抗胆碱药物。

Objective： To study the therapeutic efficacy of Penehydidin Hydrochloride （PH） in treating acute organophosphorus pesticide poisoning （AOPP） instead of Atropine. Methods： 133 cases of Aopp patients were divided into two groups： PH group and Atropine group. Those moderate and severe patients were treated PH and At- ropine plus Pralidoxine Methylchloride respectively. The efficacy and adverse reactions were compared and conducted statistical analysis. Results： There was significant differences in curative rate, efficacy, adverse reactions and motality rate between the two groups （P（0. 05）, Conclusions： PH, an ideal new anti-cholinergic drugs, is more effective than Atropine in Treating AOPP patients.